The germination in vitro is a successful technique for non-endospermic seeds. In this study, a novel method was developed for the mass production of Dendrobium anosmum ‘Di Linh’ plantlets. Using MS medium supplemented with 0.2 mg l^-1 BA, 99% of the seeds germinated and formed protocorm in a net house with no air conditioning or environmental control, or other technological aids. Shoot induction was achieved in the MS medium supplemented with 0.5 or 0.75 mg l^-1 BA, whereas their multiplication required the same medium with 0.75 mg l^-1 BA and 0.1 mg l^-1 NAA. The rooting of in vitro-established shoots was successfully achieved in the plant growth regulator-free MS medium supplemented with 1.0 g l^-1 active charcoal. Mature plantlets cultured from the net house were successfully acclimatized into ex vitro condition with, on average, a 98% survival ratio, 2.0 new shoots, and 8.3 cm of shoot length which were significantly better than those developed in the controlled room for 150 days after transplanting. The achievement of this study indicate that the net house seems to be a novel and economical method for large-scale production of D. anosmum ‘Di Linh’, not only improving plantlet quality but also saving energy and reducing product costs.